Aug 26, 2026 · 2 min listen · Last updated August 26, 2026
From storyflo. This is your daily audio brief. Chloe, August 26th. Quick run through ten health stories — let's start with the longevity piece. Let's get into it. First, from ScienceAlert. Experimental Drug Makes Obese Mice Burn Fat Without Losing Muscle – Or Eating Less.
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Daily Science Brief · August 26th
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Experimental Drug Makes Obese Mice Burn Fat Without Losing Muscle – Or Eating Less
Most weight-loss drugs work largely by reducing appetite and food intake. But an experimental compound appears to work differently: In mice, it helps the body use more of the energy it takes in. The approach could offer another way to tackle obesity. Instead of only reducing calorie intake, a treatment might also increase the calories the body uses. In a study published in Science Advances, researchers found that the compound produced an average weight loss of 18 percent in obese male mice over four weeks, without changing how much the animals ate.
Neuronal overexpression of Kcnn1 in A53T α-synuclein mice suppresses phospho-serine 129 α-synuclein formation and doubles survival time
Proceedings of the National Academy of Sciences, Volume 123, Issue 34, August 2026. SignificanceParkinson’s Disease and several other neurodegenerative diseases are driven by misfolding and aggregation of the neuronal protein α-synuclein. We studied a transgenic mouse model expressing the Parkinson’s-associated A53T mutant human α-...
Regulatory logic of neuronal differentiation in the Drosophila visual system
Proceedings of the National Academy of Sciences, Volume 123, Issue 34, August 2026. SignificanceThis study addresses a significant gap in our understanding of how different types of neurons are genetically specified. Unique combinations of transcription factors (gene regulatory proteins) in each cell type mediate this process during ...
An upstream open reading frame represses translation of the neuronal potassium channel KCNQ2
Proceedings of the National Academy of Sciences, Volume 123, Issue 34, August 2026. SignificanceProtein synthesis is controlled by several types of regulatory features within messenger RNA (mRNA). For example, upstream open reading frames (uORFs) within the 5’-untranslated region (5’-UTR) of mRNA transcripts can regulate protein ...
Coreless exoplanets induced by metal–silicate miscibility
Proceedings of the National Academy of Sciences, Volume 123, Issue 34, August 2026. SignificanceRocky exoplanets are generally assumed to differentiate into a silicate mantle and an iron core. Here we provide direct computational evidence that, under the extreme pressures and temperatures of exoplanet interiors, iron and silicate can ...