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← Storyflo·Heather's IBS Newsletter - Help for Irritable Bowel Syndrome· health

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Health

Provocative news. IBS really is a disease, not just a dysfunction?

Heather Van Vorous, Author · Heather's IBS Newsletter - Help for Irritable Bowel Syndrome

Sep 29, 2026 · 1 min listen · Last updated September 29, 2026

A new comprehensive systematic review and meta-analysis of IBS patients and studies has identified consistent inflammatory and immune biomarkers. The review was huge. It looked at 124 studies covering nearly 15,000 people with IBS, along with healthy people and those with other digestive diseases.

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Provocative news. IBS really is a disease, not just a dysfunction?

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A new comprehensive systematic review and meta-analysis of IBS patients and studies has identified consistent inflammatory and immune biomarkers.

The review was huge. It looked at 124 studies covering nearly 15,000 people with IBS, along with healthy people and those with other digestive diseases. When all the data was combined, it showed clear biological differences in people with IBS.

This is a slap in the face to the current theory that IBS is a “functional disorder” with no measurable biological basis.

University of Newcastle researcher Dr Grace Burns, of HMRI’s Immune Health Research Program, said the review found clear evidence that IBS had measurable biological features.

“IBS has often been misunderstood as a purely functional disorder,” she said.

“Our findings show there are subtle but detectable biological changes, particularly involving the immune system.”

There seems to be a shift in gastroenterology towards viewing IBS as a two-fer - it’s brain-gut disorder that interacts with underlying pathophysiological changes, instead of just the absence of disease.

This is actually quite stunning news!

And learn more about IBS

You are not alone.

P.S. If you need help or have questions hit the Green Button below and I’ll try to answer every one of you!

If you need immediate help please join my Private IBS Coaching.

XOXO

Heather

Heather Van Vorous

Over 40 years dealing with IBS

Get full help for IBS here

Get Heather’s Tummy Care here

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Provocative news. IBS really is a disease, not ... · Storyflo